Figure 4 | Cell Death & Disease

Figure 4

From: Mechanical compression induces VEGFA overexpression in breast cancer via DNMT3A-dependent miR-9 downregulation

Figure 4

Compression-induced miR-9 downregulation was reversed by decompression. (a) The effect of decompression (deCF) on miR-9 and its precursor expression. (b) Fluorescent images of miR-9 expression by decompression. Scale bar, 200 μm. (c) DNMT3A mRNA expression and (d) DNMT3A protein expression by decompression. CAF1, MDA-MB-231, and BT-474 were compressed with 1 RCU for 24 h. For decompression, the cells were cultured for an additional 24 h without compression. Data are represented as mean±S.D. ** and *** represent P-values of 0.001–0.01, and<0.001, respectively

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