Figure 5 | Cell Death & Disease

Figure 5

From: RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer

Figure 5

Enhanced tumorgenicity of RASAL2-deficient BCa cells along with the properties of stemness and mesenchymal characteristics. (a and b) Photograph pictures and quantification analysis of subcutaneous xenografts in nude mice implanted with 5637/shRASAL2-2 and 5637/scramble sublines (n=8). Xenografts weight (mg) and size (cm) were measured. (c) Immunohistochemistry staining of RASAL2, CD44 and E-cadherin in xenograft tissues from 5637/shRASAL2-2 and 5637/scramble xenograft tumors. The scale bar represents 100 μm, **P<0.01 versus control. (d) Representative BLI images of athymic BALB/c nude mice implanted with T24L/scramble and T24L/RASAL2 cells by tail-vein injection, and quantification of light emission for lung metastatic lesion was calculated (n=6)

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