Figure 4 | Cell Death & Disease

Figure 4

From: Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations

Figure 4

Potential functional interactions of PNR complexes Schematic model showing (a) proposed competition for DR1 type DNA targets; (b) possible role of PNR and PPARγ complexes in cofactor switching. Red triangles denote agonist ligands. (c) Novel heterodimeric complexes involving PNR and possible competition with TRβ/RXR and PPARγ/RXR heterodimers for dimeric partners. (d) Homology model of the PNR LBD (4LOG) indicating the distinct surfaces involved in dimerization and cofactor binding. The cofactor peptide is from a superimposed alignment of the TLX LBD in complex with atrophin corepressor peptide (4XAJ)42

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