Figure 2 | Cell Death Discovery

Figure 2

From: The interplay of autophagy and β-Catenin signaling regulates differentiation in acute myeloid leukemia

Figure 2

LecB induces apoptosis of AML cells. (a) THP-1 cells were treated with indicated concentrations of LecB for 24 h and the induction of Caspase 3/7 activity was determined. Cycloheximide (100 μg/ml) was used as positive control. Results are expressed as fold change relative to the nontreated control sample. (b) PARP cleavage was detected by western blot analysis upon LecB treatment for 24 h. The quantification illustrates the fold change of the PARP cleavage normalized to β-Actin. Values represent the mean±S.E.M. of at least three independent experiments. *P<0.05; **P<0.01.

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