Figure 5
From: Calcium oxalate toxicity in renal epithelial cells: the mediation of crystal size on cell death mode

Suggested schematic illustration of cell death mode caused by nano-/micron-sized COM and COD crystals exposure. COD-50 nm and COM-50 nm primary caused apoptotic cell death due to their small size effect and uniform and moderate injuries. COD-10 μm and COM-10 μm primary caused necrotic cell death due to their large size and local acute injuries.