Figure 2 | Cell Death Discovery

Figure 2

From: Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa

Figure 2

Necrotic changes of cone cells in the mouse model of retinitis pigmentosa. (a–f) Representative transmission electron microscopy images of the cone photoreceptor cells in wild-type (WT; a–c, n=4) and rd10 mice (e–f, n=4) at P42. The cone cells in the WT mice contained mitochondria with well-defined lamellar cristae (arrow, a and c) and cytoplasm with medium electron density (a–c). The cone cells in the rd10 mice showed swelling and vacuolation of the cytoplasm and disruption of the mitochondrial cristae (arrow, d). The swollen cone inner segments of rd10 mice (asterisk, e) were associated with plasma membrane rupture (arrowhead, f) and mitochondrial disruption (arrow, f) n, nucleus; arrow, mitochondria; arrowhead, disruption of the plasma membrane; asterisk, the inner segment of cone cells. Scale bar, 2 μm (a–d, f), 5 μm (e).

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