Figure 7 | Cell Death Discovery

Figure 7

From: Comparison of biological effects of modulated electro-hyperthermia and conventional heat treatment in human lymphoma U937 cells

Figure 7

The GeneChip heat map. The analysis revealed a whole cluster of genes, which are highly up-regulated in the case of mEHT-treated samples, but not in WHT (a). The ingenuity pathway analysis clearly demonstrated a specific gene network containing cell death-related genes, such as EGR1, JUN, and CDKN1A. The expression levels of these genes were elevated only in the cells treated with mEHT (b). A specific cytoprotective gene network (heat shock proteins, HSPs) was activated in the case of WHT treatment, but not in mEHT-treated samples (c). The ingenuity pathway analysis predicted ERK activation and the relationship between JUN and ERK in OTM-treated cells. This activation mechanism is missing in the case of WHT-treated cells (d).

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