Figure 7 | Cell Death Discovery

Figure 7

From: iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers

Figure 7

Effects on lung metastases of injecting iPS-MSCs-CD cells into preformed mammary tumors. Assays were performed on the lungs from mice from the experiment described in Figure 6. (a) RT-PCR for human GAPDH in the lungs of the treated and control groups on day 26. (b) Real time RT-PCR assays of human GAPDH in the lungs of the treated and control groups on day 26. (c) Representative images of the whole lung, and H&E-stained sections from the treated and control groups. Tumor nodule-rich areas are encircled (blue) in the control group, while the treated groups shows significant inhibition of lung metastases. Mean (±S.E.M.) tumor growth over time in mice (n=6–7 per group) injected with tumor cells and treated as indicated (**P<0.01; NS, not significant), Scale bar: 50 μm.

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