Figure 4 | Cell Death Discovery

Figure 4

From: BUB1 and SURVIVIN proteins are not degraded after a prolonged mitosis and accumulate in the nuclei of HCT116 cells

Figure 4

BUB1 and SURVIVIN showed nuclear localization after a mitotic arrest in HCT116 cells. (a) Representative images of immunostaining for BUB1, SURVIVIN and CENP-E showing kinetochore localization after 12 h of paclitaxel treatment. (b) After 24 h of paclitaxel treatment, cells that escaped from mitotic arrest showed nuclear foci localization of BUB1, nuclear localization of SURVIVIN without foci formation, and cytoplasmic localization of CENP-E. Localization of BUB1 in control (c) and 24 h paclitaxel-treated (d) HCT116 cells was determined by confocal microscopy. DAPI was used for DNA staining. Scale bar is equal to 20 μm.

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