Figure 3 | Cell Death Discovery

Figure 3

From: Development of a lytic peptide derived from BH3-only proteins

Figure 3

ABH3 induced cell death in an apoptosis-independent way. (a) Action of ABH3 on different cancer cell lines (24 h); (b) Action of ABH3 lytic peptide and ABT-737 with or without Z-VAD-FMK on HCT116 and the Bak/Bax double knockout HCT116 cell line; (c) Caspase activation in HCT116 after treatment with ABH3 and ABT-737 (10 μM, 4 h); (d) ATP depletion in HCT116 after treatment with ABH3 and ABT-737 (10 μM, 4 h). Values are expressed as mean (±S.D.) (n=3).

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