Figure 3 | Cell Death Discovery

Figure 3

From: Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation

Figure 3

Detection of fluorescent signals in nuclei of cells of vital organs of mice following i.v. injection of dead and live B16-F10 cells pre-labeled with BrdU and activation of H2AX and NFκB. One hundred thousand BrdU pre-labeled dead and live B16-F10 cells were injected i.v. into mice and animals were killed after 72 h. (a, b) Detection of fluorescent BrdU signals (left hand panels) and activation of H2AX and NFκB (middle panels) in brain, liver and lung following i.v. injection of dead and live B16-F10 cells. It is noteworthy that BrdU signals frequently co-localize with fluorescent signals generated by H2AX and NFκB activation (right hand panels).

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