Figure 9 | Cell Death Discovery

Figure 9

From: Escherichia coli O157:H7 suppresses host autophagy and promotes epithelial adhesion via Tir-mediated and cAMP-independent activation of protein kinase A

Figure 9

Model for host cell autophagy signaling induced by E. coli O157:H7. Infection of E. coli O157:H7 induces PKA activation that inhibits host autophagy activation, possibly through MAPK/ERK1/2 and ER stress signaling pathways. H89 is a specific inhibitor of PKA. The arrows indicate demonstrated effects. The blocking steps are indicated.

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