Figure 6
From: NF-κB pathway link with ER stress-induced autophagy and apoptosis in cervical tumor cells
Blocking NF-κB pathway activity by QNZ partly inhibit the autophagy and apoptosis induced by BFA in TC-1 tumor cells or HeLa cells. (a) TC-1 and HeLa cells were treated with BFA for 24 h in the presence or absence of QNZ. Whole-cell lysates were obtained and the content of LC3I and LC3II was determined by western blotting. (b) Semiquantitative expression of LC3II in western blots was measured by Gray value of LC3II in each group compared with the control group. (c) TC-1 cells and HeLa cells were treated with BFA for 24 h in the presence or absence of QNZ; protein levels of caspase-12 and cleaved caspase-3 were determined by western blotting. (d) Semiquantitative expression of caspase-12 in western blots was measured by Gray value of LC3II in each group compared with the control group.
