Figure 7 | Cell Death Discovery

Figure 7

From: Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns

Figure 7

Heatmap of gene expression profiles across divergent mtDNA ES lines. CC9mus, CC9dunni and CC9pahari ES cells, both untreated and post DNA demethylation treatment (VitC and 5-Aza), were induced to differentiate into neural lineages over 21 days and the differentiation status was compared at days 0, 3 and 21. n=3 for all undifferentiated samples and 4 for all differentiated samples. Samples were clustered in columns and gene targets were clustered in rows with the euclidean distance clustering method. The heatmap was plotted based on the Ct values normalised to the Ct value of the housekeeping gene 18S rRNA. The plot was generated using the HTqPCR package.

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