Figure 2
From: The lauric acid-activated signaling prompts apoptosis in cancer cells
Lauric acid triggers rapid responses in breast and endometrial cancer cells. (a, b) Phosphorylation of EGFR, ERK1/2 and c-Jun in SkBr3 (a) and Ishikawa (b) cells treated with vehicle (−) and 100 μM LA, as indicated. (c, d) EGFR, ERK1/2 and c-Jun activation in SkBr3 (c) and Ishikawa (d) cells treated for 60 min with vehicle or 100 μM LA alone or in combination with 10 μM EGFR inhibitor AG1478 (AG), 10 μM MEK inhibitor PD98089 (PD), 1 μM JNK inhibitor SP 600125 (SP) and 10 μM ROCK inhibitor Y-27632 (Y). EGFR, ERK2 and c-Jun were used as loading controls for pEGFR, pERK1/2 and pc-Jun, respectively. Results shown are representative of at least two independent experiments.
