Figure 3 | Cell Death Discovery

Figure 3

From: Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors

Figure 3

CB-5083-resistant cell lines harbor heterozygous mutations at exon 12 and exon 14. (a) Chromatograms displaying the region of VCP genomic DNA coding sequence at exon 12 and exon 14 in OVSAHO parental, O-CB-R2 and O-CB-R1 as well as two pure sub-clones O-CB-R1.1 and O-CB-R1.2 generated from O-CB-R1. Blue box marks codons 470, 603 and 616 that harbors mutations in the resistant clones. (b) Chromatograms displaying the region of VCP c-DNA in OVSAHO parental, OVSAHO-CB-R2, OVSAHO-CB-R1.1 and OVSAHO-CB-R1.2. Blue box marks codon 470, 603 and 616.

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