Figure 5 | Cell Death Discovery

Figure 5

From: Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors

Figure 5

Molecular docking of CB-5083 and NMS-873 into VCP. (a) A structural overview of two subunits of the VCP hexamer, with one in shades of blue and one in shades of green. The lightest shade represents the N terminal domain, the medium shade represents the D1 ATPase domain and the darkest shade represents the D2 ATPase domain, as labeled. The mutation site E470 is labeled and in red. The binding sites near the D1–D2 linker of CB-5083 and NMS-873 are labeled. (b) The primary binding mode of CB-5083, in the interface between the D1 and D2 subdomains. (c) A close-up view of the binding site of CB-5083, with distances to E470 marked. (d) The primary binding mode of NMS-873, at the interface of two VCP subunits and the D1–D2 linker, which is also in close proximity to the mutation site E470. (e) A close-up view of the primary binding mode of NMS-873, with distances to the mutation site marked in Angstrom.

Back to article page