Figure 7 | Cell Death Discovery

Figure 7

From: Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury

Figure 7

Schematic representation of UnAG action on liver mitochondria subjected to I/R. Following liver mitochondria I/R injury, UnAG rescues oxygen consumption rate and improves ATP synthase activity. Its effects are mediated by the increased expression of Opa1. The upregulation of Opa1 leads to increased CoxIV expression and subsequently improved ATP content, which, together with Bcl-2 upregulation, translates into enhanced cell survival. UnAG, Unacylated Ghrelin; Opa1, Optic atrophy 1; Bcl-2, B-cell lymphoma-2; CoxIV, Cytochrome oxydase subunit four.

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