Figure 4 | Cell Death Discovery

Figure 4

From: Parthenolide prevents resistance of MDA-MB231 cells to doxorubicin and mitoxantrone: the role of Nrf2

Figure 4

The development of resistance inhibited ROS generation. Addition of 2.0 μM PN to the drugs during the selection time reduced the inhibitory effect on ROS generation. Parental and resistant cells were treated for 1 h with 10 μM PN in order to stimulate production of ROS. At the end 10 μM H2-DCFDA were added for 20 min, then the cells were collected and employed for cytofluorimetric analysis. Results are representative of three different experiments.

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