Figure 1 | Cell Discovery

Figure 1

From: Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model

Figure 1

Differentiation of monkey induced pluripotent stem cells (iPSCs) to dopaminergic neurons. (a) Schematic representation of the differentiation procedure. (b) Immunostaining of differentiated cells on Days 7, 18, and 32. Scale bars, 50 μm. (c) Percentages of Foxa2+ cells on Days 1, 3, 5, and 7 (n=4). (d) Percentages of Nurr1+ cells on Day 18 (n=3). (e) Percentages of TH+ cells on Day 32 (n=3). (f) Fraction of Tuj-1+ cells among total cells and TH+ cells among Tuj-1+ cells on Day 32 (n=3). (g, h) Dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) levels on Day 32 before and after KCl stimulation using high-performance liguid chromatography (HPLC) methods (n=3; *P<0.05). For all the figures presented in this study, error bars represent s.e.m.

Back to article page