Figure 8
From: EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway
Disruption of TGF-β-mediated tumor suppression in SCLC cells. (a) In normal lung epithelial cells, TGF-β induces apoptosis through the suppression of ASCL1 expression in a Smad-dependent manner. (b) In SCLC cells, high EZH2 expression attenuates TβRII expression through histone H3K27 tri-methylation. Disruption of TGF-β signaling elevates ASCL1 expression, which in turn protects SCLC cells from apoptosis. SCLC, small cell lung cancer; TGF-β, transforming growth factor-β.
