Figure 1
From: Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation
Differential expression of dysbindin-1 splicing isoforms in SCZ patients and in vitro. (A and B) Schematic illustrations of three major isoforms of dysbindin-1 mRNAs and their encoding proteins: dysbindin-1A (dys1A), dysbindin-1B (dys1B) and dysbindin-1C (dys1C). (C) The relative quantity of three dysbindin-1 isoforms of mRNA in the peripheral blood leukocytes in the controls (n=98) and patients with paranoid schizophrenia (n=98), as detected by quantitative PCR (qPCR). (D) A schematic illustration of 4 SNPs identified in the intron 9 and exon 10 of DTNBP1 gene by preliminary genotyping. (E) A diagram depicting the DTNBP1 minigene construct containing exon 9, intron 9 and exon 10. (F) The relative quantity of DTNBP1b and DTNBP1(a+c) mRNA in COS7 cells (n=6), as detected by qPCR. Data are presented as mean±s.e.m. **P<0.01, ***P<0.001. CCD, coiled-coil domain; PD, PEST domain.
