Figure 5
From: Discovery of a highly potent glucocorticoid for asthma treatment
Examination of side effects of VSGC12 and FF at the effective dose. (a) Body weight of DBA/1 mice treated with the indicated daily dose of steroids for 2 weeks. Mice body weight was measured at day 0, 7 and 14. (b) Insulin-tolerance test of mice treated with the indicated daily doses of steroids for 7 days. Glucose level was measured at day 7 at various time points before and after insulin injection. Data were plotted as percent of the glucose level of time 0. (c) Plasma insulin levels of mice treated with the indicated daily doses of steroid for 7 days. (d) Spleen size and weight for mice treated with the indicated daily doses of steroid for 2 weeks. (e) Cortical bone thickness of femurs of mice treated with the indicated daily doses of steroid for 2 weeks. (f) Bone stiffness of femurs of mice treated with the indicated daily doses of steroid for 2 weeks. Mouse strain: DBA/1. Each treatment n=5, error bars indicate s.e.m., *P<0.05; **P<0.01; ***P<0.001.
