Figure 1 | Cell Discovery

Figure 1

From: Integrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers

Figure 1

Integrative analysis pipeline to predict signaling pathways affected by HRM (high risk for distant metastasis)-specific mutations. (a) Integrative analysis workflow using RNA and Exome sequencing data. Co-expression modules were generated using FPKM (fragments per kilobase of gene model per million mapped reads) values from RNA sequencing and co-expression network analysis. The modules that differentially expressed genes (DEGs) and transcription factor (TF) targets enriched (P-value<0.01) were selected as DEG-enriched co-expression modules. (b) The conceptual flow diagram of the analysis.

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