Figure 7
From: DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue
Specific knockout Akt1 in BAT increases Ucp1 expression. (a) Body mass of wild-type mice (WT) and Akt1 conditional knockout mice (Akt1 cKO) fed on a chow diet for 24 weeks(WT, n=17; Akt1 cKO, n=16). (b) MRI analysis body lean and fat mass from 25-week-old Akt1 BAT-specific knockout (Akt1 cKO) and WT littermates mice (WT, n=9; Akt1 cKO, n=9). (c) HE and Ucp1 staining of sWAT and BAT from 4-week-old mice of the Akt1 cKO and WT mice. (d) Lysates of BAT from 4-week-old WT and Akt1 cKO mice were subjected to immunoblotting with indicated antibody. (e) Model depicting the role of the DJ-1-Mib2-PTEN-Akt1- FoxO1 signaling cascade in energy balance and glucose homeostasis of BAT.
