Figure 2 | Cell Discovery

Figure 2

From: Multiplex gene regulation by CRISPR-ddCpf1

Figure 2

A proposed model for ddCpf1-mediated repression of gene transcription. The ddCpf1/crRNA complex bound to the T strand in the coding sequence of a target gene, blocking the transcription elongation of the RNAP. Alternatively, the ddCpf1/crRNA complex could bind to the promoter region of its target gene to block the transcription initiation, which was not shown in this model.

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