Table 1 Commonly deregulated and predicted gene targets of miR-21-5p in three different patient data sets

From: Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities

Gene

n softw pred.

Gastric mRNA

Head/neck miRNA/mRNA

TGCA breast miRNA/mRNA

Combined P-value

Combined P-value Stouffer

  

P-value T/N

FDR

Log2fold T/N

R Pearson

P-value Pearson

P-value T/N

FDR

Log2fold T/N

R Pearson

P-value Pearson

P-value T/N

FDR

Log2fold T/N

  

CAB39L

5

0.0001152

0.0019075

−1.4499698

−0.760

1.133E-06

1.188E-05

0.002008

−2.026

−0.226

7.82E-08

1.92E-05

2.31E-05

−0.8002

3.859E-35

0

SESN1

4

0.0051602

0.0172594

−0.9251614

−0.401

0.0280352

0.0020789

0.0449665

−0.877

−0.312

5.68E-14

0.048219

0.0151231

−1.1244375

4.821E-20

0

CDH19

5

0.0025804

0.0110663

−0.9266954

−0.669

5.281E-05

0.0046097

0.0723101

−0.723

−0.187

8.99E-06

0.0044263

0.0019835

−1.7027083

2.646E-18

5.551E-17

PLP1

4

7.931E-05

0.0016367

−1.2054348

−0.729

4.952E-06

4.833E-06

0.0014273

−1.150

−0.284

9.99E-12

0.0451993

0.0143104

−1.504125

3.314E-17

5.551E-17

SCP2

4

0.001315

0.0073171

−0.7303324

−0.427

0.018561

0.0009213

0.0265006

−0.573

−0.311

6.58E-14

0.0046633

0.0020689

−0.6649583

4.757E-16

5.211E-13

GREM2

5

6.857E-06

0.0010567

−2.0507565

−0.399

0.0288326

3.02E-05

0.0033958

−1.263

−0.178

2.59E-05

0.0325748

0.0108243

−1.7469698

2.162E-14

1.155E-11

CNTFR

6

0.0064167

0.019916

−0.6214109

−0.492

0.0057344

0.0053505

0.0785863

−0.418

−0.366

5.04E-19

2.96E-07

1.94E-06

−0.656

2.474E-13

8.092E-12

SLC16A7

3

1.304E-06

0.0009245

−3.042192

−0.592

0.0005743

4.05E-06

0.0012815

−1.316

−0.415

1.43E-24

0.030846

0.0103129

−2.09625

4.504E-13

1.82E-12

  1. Abbreviations: comb., combination; FDR, false discovery rate; N, normal; n.softw.pred., number of prediction software; T, tumor.
  2. A permutation test and a FDR procedure were used to assess a significant difference between tumoral and normal samples. A Pearson’s correlation coefficient for the miR-21-5p/mRNA pairs in matched samples of gastric, head and neck and breast cancers was evaluated. Targets were sorted by a combined correlation P-value calculated with Stouffer’s and Fisher’s methods. In bold are reported the predictive genes with the lowest p-value.
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