Figure 1

Slc39a14^−/− mice develop abnormal behavioral and motor phenotype. (a) Representative images of a wild-type (WT) and Slc39a14^−/− mouse (KO) at 8, 24 and 48 weeks of age. (b) Body weight of WT and KO littermates (n⩾4 mice/group). (c) Balance beam test results of WT and KO mice (n=3 mice/group). (d–f) Rotarod test results of WT and KO mice (n=3 mice/group). (e) The drop speed of WT and KO mice measured at 20 weeks of age (n=19 female mice and 20 male mice). (g) CatWalk analysis of a WT and KO mouse. Blue and purple represent the right forelimb (RF) and hindlimb (RH), respectively, and yellow and green represent the left forelimb (LF) and hindlimb (LH), respectively. (h–l) Analyses of CatWalk test results for WT and KO mice (n=3 mice/group). RF stands for right forelimb, LH stands for left hindlimb. *P<0.05 and **P<0.01, unpaired Student’s t-test.