Figure 6 | Cell Discovery

Figure 6

From: Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

Figure 6

Schematic model depicting the role of hepatic Slc39a14 on intracellular and systemic Mn levels. (Top) Under normal dietary Mn conditions with normal Slc39a14 levels (left), Mn is absorbed by hepatocytes via the Mn transporter Slc39a14 (shown in red) and may be exported via the Mn exporter Slc30a10 (shown in green). In contrast, loss of Slc39a14 expression leads to significantly decreased Mn levels in hepatocytes (right). (Bottom) Consuming a high Mn diet fails to overcome the reduced Mn levels in Slc39a14-knockout hepatocytes, leading to increased systemic Mn accumulation.

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