Figure 6
Distribution of Set1-binding sites on RNA. (a, b) Metagene analysis of Set1 and Set1YF/AA RNA-binding signals on mRNAs as observed by CRAC compared with polymerase occupancy (a) features aligned on transcription start site; (b) features aligned on wPAS. Insets contain zooms of relevant regions. (c) Snapshots for Set1, Set1YF/AA, and PolI CRAC normalized signals at the 5′ region of BAP2 and RPL17-A mRNAs. (d, e) Metagene analysis of Set1 and Set1YF/AA RNA-binding signals, (d) on intronless and intron-containing genes, the distribution of intron position is indicated as well as the average position of introns; (e) to cryptic unstable transcripts (CUTs) compared with size matched open reading frame (ORF).
