Figure 4
From: Tumor-targeted delivery of biologically active TRAIL protein
Efficacy of sTRAIL-expressing E. coli DH5α on tumor growth and animal survival in vivo when administered systematically. (a) Quantitative efficacy of sTRAIL-expressing E. coli DH5α on the growth of H460 tumors in nude mice after intravenous injection. Tumor volume (mm3) was measured by external calipers twice per week and calculated as described under Materials and methods. Each point represents the mean for n=20 animals. The experiment was repeated independently at least three times with similar results. The arrows indicate time points at which treatment was given. (b) Effect of sTRAIL-expressing E. coli DH5α on the survival of animals bearing subcutaneous H460 xenografts. Animals (n=20) were treated as described under Materials and methods. sTRAIL, soluble TRAIL; TRAIL, tumor necrosis factor (TNF)-related apoptosis-inducing ligand.
