Figure 1
HA behaves as a potent tumor-associated antigen that elicits efficient effector responses in the absence of Tregs. (a) Six-week-old BALB/c mice were injected s.c. with 5 × 105 AB1-HA (black line) or AB1 (gray line) tumor cells at day 0 (n=5 in each group). Graph shows the tumor volume growth (mm3) of each tumor line. One representative of >5. (b) Six-week-old BALB/c mice were injected s.c. with 5 × 105 AB1-HA (n=12, circle) or AB1 (n=12, square) tumor cells at day 0 after Treg depletion by a single injection i.v. of 125 μg PC61 at day −1 (n=10 in each group). Graph shows the tumor volume growth (mm3) of each tumor line at day 25 in the absence of Tregs. AB1-HA tumor volumes were statistically different from AB1 tumor volumes (***P=0.0006, with an unpaired t-test). Five independent experiments were conducted.
