Table 1 Sequence design of HPV-siRNAs

From: Highly potent and specific siRNAs against E6 or E7 genes of HPV16- or HPV18-infected cervical cancers

HPV-siRNA

Nucleotides

siRNA sequence

16E6-249 (249-267)

19

5′-TTATGCATAGTATATAGAGgaagcttgCTCTATATACTATGCATAA-3′

16E6-164 (164-183)

20

5′-CTAGGCAAACAACTATACATGATAgaagcttgTATCATGTATAGTTGTTTGC-3′

16E6-161 (161-178)

18

5′-CTAGCTGCAAACAACTATACATgaagcttgATGTATAGTTGTTTGCAG-3′

16E7-666 (666-682)

17

5′-GAAATAGATGGTCCAGCgaagcttgGCTGGACCATCTATTTC-3′

16E7-629 (629-645)

17

5′-CTAGCTCTACTGTTATGAGCAgaagcttgTGCTCATAACAGTAGAG-3′

16E7-628 (628-649)

22

5′-CTAGTCTCTACTGTTATGAGCAATTAgaagcttgTAATTGCTCATAACAGTAGAGA-3′

18E6-119 (119-125)

17

5′-CCAACACGGCGACCCTAgaagcttgTAGGGTCGCCGTGTTGG-3′

18E6-Scramble

17

5′-CACCACATACCGCACGGgaagcttgCCGTGCGGTATGTGGTG-3′

18E7-666 (666-682)

17

5′-CTAGTTCTATGTCACGAGCAAgaagcttgTTGCTCGTGACATAGAA-3′

18E7-674 (674-690)

17

5′-CTAGCACGAGCAATTAAGCGAgaagcttgTCGCTTAATTGCTCGTG-3′

  1. Abbreviations: HPV, human papillomaviruse; siRNA, small interfering RNA.
  2. The position of each siRNA target sequence from the transcriptional start site is shown in parentheses. All siRNAs sequences have been confirmed by BLAST to have no homology to any part of the human genome. The nucleotide sequences in lowercase letters indicate the spacer for the hairpin folding area.