Figure 4
Cytotoxic efficacy of prodrug convertase CD/UPRT. HNO97, HNO210, HNO410 and Vero-αHis (104 cells each) were infected in quadruplicates with MV-CD-antiEGFR (triangle) at a MOI of 0.01 (continuous line), 0.1 (broken) or 1 (dotted) for 36 h and incubated without 5-FC (left column) or with 1 mM 5-FC (right column). Cell viability was determined at the indicated time points after infection. Means (and standard deviations only for values at 96 h) are shown (circle/continuous line, mock-treated cells defining 100% viability; square/continuous line, 5-FC only treated).
