Table 1 GFI1B expression in K562, primary CML cells and hematopoietic progenitor cells measured by real-time RT-PCR

From: Additive antileukemia effects by GFI1B- and BCR–ABL-specific siRNA in advanced phase chronic myeloid leukemic cells

Disease

GFI1B expression (%)

P-value compared with healthy volunteers CD34+ cells

K562 (n=18)

218.4±96.7

<0.01

CML in first chronic phase (n=10)

36.7±13.6

<0.01

CML in advanced phase (n=4)

58.2±13.5

<0.01

CML in blastic crisis (n=4)

122.9±52.1

<0.04

Healthy volunteers

 CD34+ cells (n=2)

1.65±0.35

 CD34 cells

0.16±0.01

NS

  1. Abbreviations: CML, chronic myeloid leukemia; NS, not-significant; RT-PCR, reverse transcription-polymerase chain reaction.
  2. GFI1B mRNA expression was measured and shown as mean (with s.d.) normalized to GAPDH housekeeping gene expression and compared with gene expression in hematopoietic progenitor cells of healthy volunteers.