Figure 4
From: Role of MAPK in oncolytic herpes viral therapy in triple-negative breast cancer
NV1066 has synergistic effects with PD98059, both inhibiting MEK and downregulating the MAPK pathway. (a) Fraction-affected-Combination index (Fa-CI) plot using a constant ratio combination method. Plot was generated automatically by using CompuSyn. Combination index (CI) values<1 indicates synergism. (b) Immunoblotting of MEK and MAPK and (c) cleaved PARP (an indicator of apoptosis) from cell lysates used from the synergy experiment performed in 4A after 3 days of treatment. Actin is shown as loading control.
