Table 1 Combination index (CI) values calculated using the Chou and Talalay method for synergy experiment combining NV1066 with MEK inhibitor PD98059

From: Role of MAPK in oncolytic herpes viral therapy in triple-negative breast cancer

NV1066 (MOI)

PD98059 (mM)

Fa

CI value

0.1

12.5

0.128

0.599

0.2

25

0.240

0.501

0.4

50

0.323

0.623

0.8

100

0.487

0.571

1.2

150

0.590

0.545

1.6

200

0.614

0.638

  1. The synergistic effect is demonstrated by a CI <1 across a wide range of concentrations. Fraction-affected (Fa) denotes fraction affected, (Fa of 0.75 is equivalent to a 75% reduction of cell growth).
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