Figure 2
From: The challenges of solid tumor for designer CAR-T therapies: a 25-year perspective
Structure of first- and second-generation CARs. The first-generation CAR is linked to the signaling domain of TCR ζ-chain, generating Signal 1 on antigen contact. The second-generation CAR incorporates the CD28 signaling domain together with TCR-ζ, generating Signal 1+2 on antigen contact.
