Table 6 Genotype and allele frequencies of TNF-α-863C/A between the T-MG and NT-MG groups

From: Correlations of TNF-α gene promoter polymorphisms with the risk of thymoma-associated myasthenia gravis in a northern Chinese Han population

Subject

Case

Genotype

Allele

  

CC

CA

AA

C

A

NC group

293

184 (62.80)

91 (31.06)

18 (6.14)

459 (78.33)

127 (21.67)

 Male

128

75 (58.59)

48 (37.50)

5 (3.91)

198 (77.34)

58 (22.66)

 Female

165

109 (66.06)

43 (26.06)

13 (7.88)

261 (79.09)

69 (20.91)

Anti-AchR-positive

86

53 (61.63)

30 (34.88)

3 (3.59)

136 (79.07)

36 (20.93)

Anti-AchR-negative

207

131 (63.29)

61 (29.47)

15 (7.25)

323 (78.02)

91 (21.98)

NT-MG group

184

116 (63.04)

52 (28.26)

16 (8.70)

284 (82.07)

84 (17.93)

T-MG group

121

76 (62.81)

37 (30.58)

8 (6.61)

189 (78.10)

53 (21.90)

 Male

150

96 (64.00)

46 (30.67)

8 (5.33)

238 (79.33)

62 (20.67)

 Female

155

96 (61.94)

43 (27.74)

16 (10.32)

235 (75.81)

75 (24.19)

Anti-AchR-positive

110

77 (70.00)

26 (23.64)

7 (6.36)

180 (81.82)

40 (18.18)

Anti-AchR-negative

195

115 (58.97)

63 (32.31)

17 (8.72)

293 (75.13)

97 (24.87)

Ocular

126

79 (62.70)

37 (29.37)

10 (7.94)

195 (77.38)

57 (22.62)

Generalized

179

113 (63.13)

52 (29.05)

14 (7.82)

278 (77.65)

80 (22.35)

  1. Abbreviations: anti-AchR, acetylcholine receptor antibody; NT-MG, nonthymoma-associated myasthenia gravis; T-MG, thymoma-associated myasthenia gravis; TNF-α, tumor necrosis factor-alpha.