Figure 1

Effect of chrysin on the fundus and histological manifestations of EAU. (a) Fundal images of control mice and chrysin-treated mice. Retinal infiltration, vasculitis and papilledema were observed in the control mice, and these effects were scarcely found in the chrysin-treated mice. The clinical scores were significantly decreased in the chrysin-treated group compared with the control group (*P<0.01; n=6 mice). (b) H&E staining. The control mice had more severe vasculitis (black arrow), vitreous infiltration (red arrow) and photoreceptor cell layer infiltration (white asterisk), as compared with the chrysin-treated mice (original magnification × 100). The histopathological scores were significantly decreased in the chrysin-treated group compared with the control group (**P<0.01; n=6 mice). EAU, experimental autoimmune uveitis; H&E, hematoxylin and eosin.