Figure 2
From: Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development
Cell-autonomous and long-lasting effect of Trap1a mutation on thymocyte production. (a) Diagram of experimental design. (b) Evidence of partial enrichment of mutant bone marrow cells by negative selection with anti-CD45.1 beads. (c) Impact of Trap1a mutation on thymocyte production in serial transplantation. Data shown are representative profiles of first and second transplantation. (d) Selective reduction of thymocyte production after Trap1a deletion. Data shown are % of WT and Trap1a−/y leukocytes at 4 or 11 weeks after second transplantation. (e) Trap1a deletion causes selective reduction of T cells and increase of myeloid cells in the peripheral blood at 11 weeks after second transplantation. **P<0.01; ***P<0.001. WT, wild type.
