Figure 2 | Cellular & Molecular Immunology

Figure 2

From: Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor

Figure 2

C5a-dependent GN in FH−/− mice with CSS. CSS was induced in FH−/− mice by daily immunization with apoferritin, or saline alone as control. Groups of animals also received C5aRant and/or CPinh after 2 and 3 weeks, respectively. (A) Individual values of semiquantitative GN scores from all mice studied. The horizontal lines are the median values in each group. The boxes enclose Q1–Q3 intervals. Groups were significantly different by Kruskall–Wallis testing (P < 0.001), with between-group comparisons shown in the Figure. (B–E) Representative PAS staining of glomeruli from mice from the different groups. Original magnifications, ×400.

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