Figure 4 | Cellular & Molecular Immunology

Figure 4

From: Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut

Figure 4

Mechanism of suppression of allergen-specific Th2 production. Sensitized mice were EPIT-, OIT-, SLIT- or sham-treated for 8 weeks. At the end of the treatment, the spleen cells were harvested and stimulated with peanut in the presence or absence of anti-IL-10 or anti-CTLA-4 blocking antibodies for 72 h. The IL-5 (a) and IL-13 (b) levels in the supernatant were measured using Bioplex. The data are shown as the median with range from three independent experiments with n=6 for each group of mice. *P<0.05; **P<0.01; ***P<0.001; #P<0.05 compared with EPIT.

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