Figure 6 | Cellular & Molecular Immunology

Figure 6

From: Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut

Figure 6

Induction of Tregs and their expression of homing receptors in the iLN and mLN. Sensitized mice were EPIT-, OIT-, SLIT- or sham-treated for 8 weeks. At the end of treatment, the iLN (a–d) and mLN (e–h) cells were harvested for flow cytometric analysis. The cells were gated on CD4+ among the lymphocytes identified by FSC/SSC after doublet exclusion, and the percentages of CD25+Foxp3+ (a, e), the percentage of CD4+CD25+Foxp3+ cells expressing either only CCR9 (CCR9+CLA−) (b, f), both CCR9 and CLA (CCR9+CLA+) (c, g) or only CLA (CCR9-CLA+) (d, h) were analyzed. The data are shown as the median with range from three independent experiments, with n=6 for each group of mice. *P<0.05; **P<0.01; ***P<0.001; #P<0.01 compared with EPIT.

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