Figure 7 | Cellular & Molecular Immunology

Figure 7

From: Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut

Figure 7

Sustainability of different Tregs induced by EPIT, OIT or SLIT. Sensitized mice were EPIT-, OIT-, SLIT- or sham-treated for 8 weeks and left untreated for 8 more weeks. The spleen cells were harvested for flow cytometry analysis. The percentages of CD25+Foxp3+ (a), CD25+IL10+ (b) and CD25+Foxp3+CD44hiCD62L− or CD25+Foxp3+CD44loCD62L+ (c) were analyzed. (d) Using the same gating strategies, the cells were gated on CD4+CD25+Foxp3+ and the percentage of cells expressing CTLA-4 was analyzed. The percentages of CD4+CD25+Foxp3+ cells expressing CCR6 (e), CXCR3 (f), CCR3 (g), CCR8 (h), CLA (i) or CCR9 (j) was analyzed. The data are shown as the median with range from three independent experiments with n=6 for each group of mice. *P<0.05; **P<0.01; ***P<0.001; #P<0.01 compared with EPIT.

Back to article page