Table 1 Viruses and intracellular DNA sensors

Virus	DNA sensor	Experimental system(s)	Biological response	References
HSV-1	cGAS	Mice	Type I IFN	³⁴
HSV-1	IFI16	Human macrophages and human fibroblasts	Type I IFN, IL-1β	^{27, 35, 87}
HCMV	IFI16	Human macrophages and human fibroblasts	Type I IFN	^{27, 36}
MCMV	AIM2	Mice	IL-18	³²
MHV68	cGAS	Mice	Type I IFN	³³
KSHV	IFI16	Human dermal microvascular endothelial cells	IL-1β	⁸⁸
EBV	IFI16	Human B cell lines	IL-1β	⁸⁹
AdV	cGAS	Murine macrophage and endothelial cell lines	Type I IFN	⁹⁰
VV	AIM2	Murine macrophages	IL-1β	¹⁵
HIV-1	IFI16	Human macrophages and human T cells	Type I IFN, pyroptosis	^{30, 91}
HIV-1	cGAS	Human macrophages	Type I IFN response	^{30, 42}

Abbreviations: AdV, adenovirus; cGAS, cyclic GMP–AMP synthase; EBV, Epstein-Barr virus; HCMV, human cytomegalovirus; HSV, herpes simplex virus-1; IL, interleukin; IFN, interferon; KSHV, Kaposi’s sarcoma-associated herpesvirus; MCMV, murine CMV; MHV68, murine gammaherpesvirus 68; VV, vaccinia virus.

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