Figure 1 | Cellular & Molecular Immunology

Figure 1

From: IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity

Figure 1

IL-25 correlates with BMI in NAFLD patients and is decreased in the eWAT and liver of diet-induced obese mice. (a, b) The level of IL-25 in the serum (a) and liver (b) compared with the BMI of control and NAFLD patients. An ELISA was used to measure the level of IL-25. NAFLD n=14, control n=8; *P<0.05 versus the control group. (c, d) The expression of IL-25 in the serum (c) and liver (d) of mice fed with an HFD at different time points. An ELISA was used to measure the level of mouse IL-25. The data are presented as the mean±s.d. of three independent experiments. n=5; *P<0.05 versus the 0-W group. (e, f) The expression of IL-25 in the livers (e) and eWAT (f) of mice fed with NCD/HFD. The level of IL-25 was measured by an ELISA and qPCR in the liver or eWAT. The data are presented as the mean±s.d. of three independent experiments. n=5; *P<0.05 versus the NCD group. BMI, body mass index; eWAT, epididymal white adipose tissue; HFD, high-fat diet; IL, interleukin; NAFLD, nonalcoholic fatty liver disease; NCD, normal chow diet; qPCR, quantitative real-time PCR.

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