Figure 7 | Cellular & Molecular Immunology

Figure 7

From: IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity

Figure 7

A proposed model for the immunometabolism roles and functions of IL-25 related to macrophages and adipocytes. This schema summarizes the main roles and functions of IL-25 in lipid metabolism. IL-25 can polarize macrophages into the M2 phenotype and secrete type-2 cytokines/mediators to promote fat mobilization, release FFA, enhance the lipid uptake by macrophages, improve the mitochondrial respiratory capacity and promote energy expenditure against obesity. FFA, free fatty acid; IL, interleukin.

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