Table 1 A summary of dysregulated epigenetic modifications in B cells in diseases
From: Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity
Diseases | Modifications | Targeting genes | Consequences | Referencce |
|---|---|---|---|---|
DNA methylation | ||||
?SLE | DNA demethylation | Global DNA | Auto-reactive B cells | |
?SLE | DNA demethylation | HRES1/p28 | HERV dysreguation | |
?SLE | DNA hypomethyaltion | LINE-1 | — | |
?SLE | Lower levels of DMNT1 and DNMT3b, DNA demethylation | Global DNA | Auto-reactive B cells | |
?T1D | An enrichment of differentially variable CpG positions | — | — | |
MicroRNAs | ||||
?SLE | mir-30a, increased | Lyn | Overactive B cells | |
?SLE | mir-155 and mir-181b, increased | AID | Regulating B-cell antibody diversification | |
?SLE | mir-15a in regulatory B cells, increased | — | — | |
?SLE | mir-1246, increased | EBF1 | Overactive B cells | |
?SLE | mir-21, mir-17-92, increased | — | — | |
?RA | mir-155 | PU.1 | Affecting B-cell function | |
?RA | mir-29a | — | Regulating B-cell proliferation and antibody production | |
