Abstract
Neural stem cells (NSCs) are present not only during the embryonic development but also in the adult brain of all mammalian species, including humans. Stem cell niche architecture in vivo enables adult NSCs to continuously generate functional neurons in specific brain regions throughout life. The adult neurogenesis process is subject to dynamic regulation by various physiological, pathological and pharmacological stimuli. Multipotent adult NSCs also appear to be intrinsically plastic, amenable to genetic programing during normal differentiation, and to epigenetic reprograming during de-differentiation into pluripotency. Increasing evidence suggests that adult NSCs significantly contribute to specialized neural functions under physiological and pathological conditions. Fully understanding the biology of adult NSCs will provide crucial insights into both the etiology and potential therapeutic interventions of major brain disorders. Here, we review recent progress on adult NSCs of the mammalian central nervous system, including topics on their identity, niche, function, plasticity, and emerging roles in cancer and regenerative medicine.
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Acknowledgements
The research in the laboratories of Ming and Song was supported by the NIH (NS047344, AG024984, MH084018, NS048271), March of Dimes, Sloan, Maryland Stem Cell Research Fund (MSCRF), USA, NARSAD, McKnight Foundation, Packard Center for ALS and MDA. MA.B was supported by a postdoctoral fellowship from MSCRF.
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Ma, D., Bonaguidi, M., Ming, Gl. et al. Adult neural stem cells in the mammalian central nervous system. Cell Res 19, 672–682 (2009). https://doi.org/10.1038/cr.2009.56
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